Telephone: (02) 2787-1262.
Email: wcheng@gate.sincia.edu.tw
Education
2002 Ph
D. Department of Chemistry, University
of California, Davis, CA, USA
1993 M.S. Department
of Chemistry,
National Tsing-Hua University, Hsinchu, Taiwan
1991 B.S. Chemistry, National Cheng-Kung National
University, Taiwan
Professional Experience
2010-present Associate Research Fellow, Genomics Research
Center, Academia Sinica, Taipei, Taiwan
2004-2010
Assistant Research Fellow,
Genomics Research Center, Academia Sinica,
Taipei, Taiwan
2002-2004
Postdoctoral Fellow, The Scripps
Research Institute, USA
Honors
2013 Outstanding
Young Researcher Grants, Taiwan
2007 The distinguished
lectureship award (Natural products synthesis), The CSJ (Chemical society of
Japan) Asian International Symposium, Japan, 2007
2002-2004 The Skaggs postdoctoral Fellowship
Research Experience
Dr. Cheng received his B.S. (1991) degree
in Chemistry from National Cheng-Kung University, Taiwan and M.S. (1993) degree
in Chemistry from National Tsing-Hua University, Taiwan. After military service
(two years) and experience as a research assistant, he started his Ph.D.
program at UC-Davis, USA in 1997. He received his Ph.D. degree in Chemistry
from University of California, Davis, CA, USA (1997-2002). He then worked in Chemistry
at the Scripps Research Institute, San Diego, USA as a postdoctoral fellow
(2002-2004). Dr. Cheng started his independent career as Assistant Research
Fellow at the Genomics Research Center at Academia Sinica, Taipei, Taiwan in
2004 and became Associate Research Fellow in 2010.
Research Interests
The major research efforts of our group are directed toward the development of new synthetic strategies for biologically interesting natural products and
heterocycles. To understand the relationships between small molecules and
biological systems, combinatorial approaches are applied in our diverse
molecule library synthesis (core diversity, substituent diversity, and
configuration diversity) with the assistance of automated or semi-automated
equipment. Research interests include: Organic chemistry, Synthetic methodology, Natural product
and bioactive molecule synthesis, Matrix-supported organic synthesis,
Combinatorial chemistry, Synthesis of new glycophospholipids, Synthesis and
functional study of Novel iminosugar alkaloids, Natural product-like library
synthesis, Synthesis of bacterial (mycobacterial) cell wall components,
Development of new chemical probes for biological applications, Pathogen host
interaction, New molecules for innate immune study, Bioorganic chemistry, Chemical
biology, Small molecules as chemical chaperones or specific stabilizers of
protein drugs for potential treatments of lysosomal storage diseases, Development
of new antibiotics, and Drug discovery. Recently, our lab is dedicated to “natural
product inspired combinatorial chemistry” and its applications.
Publications
1. Wei-Chieh Cheng,* Cheng-Kun Lin, Huang-Yi Li, Yu-Chien Chang, Sheng-Jhih Lu, Yu-Shin
Chen, Shih-Ying Chang, “A combinatorial
approach towards the synthesis of non-hydrolysable triazole–iduronic acid
hybrid inhibitors of human α-L-iduronidase: discovery of enzyme stabilizers for
the potential treatment of MPSI”. Chem. Commun., 2018, 54, 2647 – 2650
2. Wei-Shen Wu, Wei-Chieh Cheng, Ting-Jen R.
Cheng, and Chi-Huey Wong, Affinity-Based
Screen for Inhibitors of Bacterial Transglycosylase, Journal of the American Chemical
Society 2018 140 (8), 2752-2755
3.
Huang-Yi Li, Jay-Der Lee, Chiao-Wen Chen, Ying-Chieh Sun, and Wei-Chieh Cheng*, “Synthesis of (3S,4S,5S)-trihydroxylpiperidine derivatives as
enzyme stabilizers to improve therapeutic enzyme activity in Fabry patient cell
lines”,
Eur
J Med Chem. 2018,
144, 626-634.
4. Kuo-Ting Chen, Yi-Fan Chang, Chia-Ming Hu, Cheng-Kun Lin, Ting-Jen R. Cheng and Wei-Chieh Cheng*, “Effect of the Lipid II Sugar Moiety
on Bacterial Transglycosylase: the 4-Hydroxy Epimer of Lipid II is a
TGase Inhibitor”, Chem. Commun., 2017, 53, 771-774
5.
Wei-Chieh Cheng*,
Jen-Hon Wang,Wen-Yi Yun,Huang-Yi Li, Jia-Ming Hu,”Rapid
preparation of (3R,4S,5R) polyhydroxylated pyrrolidine-based libraries
to discover a pharmacological chaperone for treatment of Fabry disease”, Eur
J Med Chem. 2017, 126, 1-6.
6.
Kuo-Ting Chen,
Po-Ting Chen, Cheng-Kun Lin, Lin-Ya Huang, Chia-Ming Hu, Yi-Fan Chang, Hua-Ting
Hsu, Ting-Jen R. Cheng, Ying-Ta Wu and Wei-Chieh Cheng*, “Structural Investigation of Park’s
Nucleotide on Bacterial Translocase MraY: Discovery of Unexpected MraY Inhibitors“, Scientific Reports, 2016, 6, 31579.
7.
Cheng-Kun Lin, Chung-Chien Hou,
Yi-Yong Guo, and Wei-Chieh Cheng.*, “Design and Synthesis of Orthogonally
Protected D- and L-β-Hydroxyenduracididines from D-Lyxono-1,4-lactone”, 2016, Org Lett., 18,
5216-5219.
8.
Wei-Chieh Cheng*, Wang JH, Li HY, Lu SJ, Hu JM, Yun WY, Chiu CH, Yang WB, Chien YH, Hwu WL,, “Bioevaluation of sixteen ADMDP stereoisomers
toward alfa-galactosidase A: Development of a new pharmacological chaperone for
the treatment of Fabry disease and potential enhancement of enzyme replacement
therapy efficiency”, Eur
J Med Chem. 2016, 123, 14-20.
9.
Cheng-Kun Lin,
Wen-Yi Yun, Lin-Ting Lin
and Wei-Chieh Cheng* ,
A Concise Approach Towards the Synthesis of the Unique N-Mannsoyl
D-β-Hydroxyenduracididine Moiety in the Mannopeptimycin Series of Natural
Products, Org. Biomol. Chem., 2016, 14, 4054-4060
10. Johannes Zuegg, Craig Muldoon, George Adamson, Declan McKeveney,
Giang Le Thanh, Rajaratnam Premraj, Bernd Becker, Mu Cheng, Alysha G. Elliott,
Johnny X. Huang, Mark S. Butler, Megha Bajaj, Joachim Seifert, Latika Singh,
Nicola F. Galley, David I. Roper, Adrian J. Lloyd, Christopher G. Dowson,
Ting-Jen Cheng, Wei-Chieh Cheng,
Dieter Demon, Evelyne Meyer, Wim Meutermans, Matthew A. Cooper*, “Carbohydrate
scaffolds as glycosyltransferase inhibitors with in vivo antibacterial
activity”, Nat. Commun., 2015, 6, 7719.
11. Cheng-Kun Lin, Li-Wei Cheng, Huang-Yi Li, Wen-Yi Yun, Wei-Chieh Cheng*, “Synthesis of
Novel Polyhydroxylated Pyrrolidine–triazole/-isoxazole Hybrid Molecules”, Org. Biomol. Chem. 2015, 13, 2100–2107.
12. Po-Ting Chen, Cheng-Kun Lin, Chih-Ju Tsai, Duen-Yi Huang, Fu-Yao
Nien, Wan-Wan Lin, Wei-Chieh Cheng*,
“Expeditious Synthesis of Enantiopure, Orthogonally Protected Bis α-Amino Acids
(OPBAAs) and their Use in a Study of Nod1 Stimulation”, Chem. Asian J. 2015, 10, 474–482.
13. Wei-Chieh Cheng*, Chih-Wei Guo, Cheng-Kun Lin, Yu-Ruei
Jiang, “Synthesis and Inhibition Study of Bicyclic Iminosugar-Based Alkaloids,
Scaffolds, and Libraries towards Glucosidase”, Isr. J. Chem. 2015, 55(3-4), 403-411.
14. Cheng-Kun Lin, Kuo-Ting Chen, Chia-Ming Hu, Wen-Yi Yun, Wei-Chieh Cheng*, “Synthesis of
1-C-glycoside Linked Lipid II Analogues toward Bacterial Transglycosylase
Inhibition Study”, Chem. Eur. J. 2015, 21, 7511-9.
15. Kuo-Ting Chen, Duen-Yi
Huang, Cheng-Hsin Chiu, Wan-Wan Lin, Pi-Hui
Liang, Wei-Chieh
Cheng*, “Synthesis of Diverse N-Substituted
Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2
Stimulation Activity. ”
Chem. Eur. J. 2015, 21, 11984-11988.
16. Tseng, Yen-Yu; Liou, Jyh-Ming; Hsu, Tsui-Ling; Cheng, Wei-Chieh; Wu, Ming-Shiang*; Wong, Chi-Huey*, 2014, “Development
of bacterial transglycosylase inhibitors as new antibiotics: moenomycin A
treatment for drug-resistant Helicobacter pylori.”, Bioorganic
& medicinal chemistry letters, 24(11),
2412-2414. (SCI)
17. Huang, Lin-Ya; Huang, Shih-Hsien; Chang,
Ya-Chih; Cheng, Wei-Chieh; Cheng, Ting-Jen R.*; Wong, Chi-Huey*, 2014, “Enzymatic Synthesis of Lipid II and Analogues.”, Angewandte
Chemie-International Edition, 53(31),
8060-8065. (SCI)
18. Hsu, Che-Hsiung; Schelwies, Mathias; Enck, Sebastian; Huang, Lin-Ya;
Huang, Shih-Hsien; Chang, Yi-Fan; Cheng, Ting-Jen Rachel; Cheng,
Wei-Chieh; Wong, Chi-Huey*, 2014, “Iminosugar C-Glycoside Analogues of
alpha-d-GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase
Inhibition. ”, The Journal of Organic Chemistry, 79(18), 8629-8637.
(SCI)
19. Huang, S.-H.; Wu, W.-S.; Huang, L.-Y.;
Huang, W.-F.; Fu, W.-C.; Chen, P.-T.; Fang, J.-M.; Cheng, W.-C.*; Cheng, T.-J.*; Wong, C.-H.*, New continuous fluorometric assay for bacterial transglycosylase
using Forster resonance energy transfer., J. Am. Chem.
Soc. 2013, 135, 17078-89.
20. Cheng, W.-C.*; Weng, C.-Y.; Yun,
W.-Y.; Chang, S.-Y.; Lin, Y.-C.; Tsai, F.-J.; Huang, F.-Y.; Chen, Y.-R., Rapid modifications of N-substitution in iminosugars: development of
new beta-glucocerebrosidase inhibitors and pharmacological chaperones for
Gaucher disease., Bioorg. Med. Chem. 2013, 21, 5021-8.
21.
Chen K.-T.; Kuan Y.-C.; Fu W.-C.; Liang P.-H.; Cheng T.-J.; Wong
C.-H.; Cheng W.-C.*, Rapid preparation of mycobacterium N-glycolyl Lipid I and Lipid II
derivatives: a biocatalytic approach., Chem. Eur. J. 2013, 19, 834-8.
22. Pan
Y.-W.; Guo C.-W.; Tu H.-Y.; Tsai C.-W.; Cheng W.-C.*, Solid-Phase
Synthesis of Diverse Spiroisoxazolinodiketopiperazines. ACS Comb. Sci. 2013, 15,
425-34.
23. Cheng, T.-J.;
Chan, T.-H.; Tsou, E.-L.,; Chang, S.-Y.; Yun, W.-Y.; Yang, P.-J.; Wu, Y.-T.; Cheng, W.-C.*, From Natural Product-Inspired Pyrrolidine Scaffolds to the
Development of New Human Golgi alpha-Mannosidase II Inhibitors., Chem. Asian J. 2013, 8, 2600-4.
24. Shih, H.-W.; Chang, Y.-F.; Li, W.-J.; Meng, F.-C.; Huang, C.-Y.; Ma,
C.; Cheng, T.-J. R.; Wong, C.-H.; Cheng,
W.-C.*, Effect of the Peptide Moiety of Lipid II on Bacterial
Transglycosylase, Angew. Chem. Int. Ed.
2012, 51, 10123-26. (IF: 13.4) (corresponding
author, (corresponding author, 7/152 in chemistry, multidisciplinary)
25. Huang, C.-Y.; Shih, H.-W.; Lin, L.-Y.;
Tien, Y.-W.; Cheng, T.-J. R.; Cheng, W.-C.; Wong, C.-H.; Ma, C.: Crystal
structure of Staphylococcus aureus transglycosylase in complex with a lipid II
analog and elucidation of peptidoglycan synthesis mechanism. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 6496-6501.
26. Shih, H.-W.; Chen, K.-T.; Cheng, W.-C.: One-pot
synthesis of phosphate diesters and phosphonate monoesters via a combination of
microwave-CCl3CN-pyridine coupling conditions. Tetrahedron Lett. 2012, 53, 243-246. (corresponding author)
27. Hsu, Y.-C.; Chen, N.-C.; Chen, P.-C.; Wang,
C.-C.; Cheng, W.-C.; Wu, H.-N.: Identification of a small-molecule inhibitor of
dengue virus using a replicon system. Arch.
Virol. 2012, 157, 681-688.
28. Meng, F.-C.; Chen, K.-T.; Huang, L.-Y.;
Shih, H.-W.; Chang, H.-H.; Nien, F.-Y.; Liang, P.-H.; Cheng, T.-J. R.; Wong, C.-H.;
Cheng, W.-C.: Total Synthesis
of Polyprenyl N-Glycolyl Lipid II as a Mycobacterial Transglycosylase
Substrate. Org. Lett. 2011, 13, 5306-5309. (IF: 5.25) (corresponding
author, 4/55 in chemistry, organic)
29. Shih, H.-W.; Chen, K.-T.; Cheng, T.-J. R. Wong, C.-H.; Cheng, W.-C. A new synthetic
approach toward bacterial transglycosylase substrates, Lipid II and Lipid IV. Org. Lett. 2011, 13 (17), 4600-4603. (IF: 5.25) (corresponding author, 4/55 in chemistry, organic)
30. Chang, Y.-F.; Guo, C.-W.; Chan, T.-H.; Pan,
Y.-W.; Tsou, E.-L.; Cheng, W.-C.,
Parallel synthesis of natural product-like polyhydroxylated pyrrolidine and
piperidine alkaloids. Mol. Diversity 2011, 15 (1), 203-214. (IF: 2.071) (corresponding author, 4/61 in chemistry, applied).
31. Su, C.-Y.; Cheng, T.-J. R.; Lin, M.-I.;
Wang, S.-Y.; Huang, W.-I.; Lin-Chu, S.-Y.; Chen, Y.-H.; Wu, C.-Y.; Lai, M.-C.
M.; Cheng, W.-C.; Wu, Y.-T.;
Tsai, M.-D.; Cheng Y.-S. E.*; Wong, C.-H.*, High-throughput identification of
compounds targeting influenza RNA-dependent RNA polymerase activity. Proc.
Natl. Acad. Sci. U.S.A. 2010,
107 (45), 19151-6. (IF: 9.432) (co-author;
times cited: 2; 3/42
in multidisciplinary, science)
32. Shih, H.-W.; Chen, K.-T.; Chen, S.-K.;
Huang, C.-Y.; Cheng, T.-J. R.; Ma, C.; Wong, C.-H.*; Cheng, W.-C.*, Combinatorial approach toward synthesis of
small molecule libraries as bacterial transglycosylase inhibitors. Org.
Biomol. Chem. 2010, 8
(11), 2586-2593. (IF: 3.762) (corresponding author, 10/55
in chemistry, organic)
33. Liu, C.-Y.; Guo, C.-W.; Chang, Y.-F.;
Wang, J.-T.; Shih, H.-W.; Hsu, Y.-F.; Chen, C.-W.; Chen, S.-K.; Wang, Y.-C.;
Cheng, T.-J. R.; Ma, C.; Wong, C.-H.; Fang, J.-M.*; Cheng, W.-C.*, Synthesis and evaluation of a new fluorescent
transglycosylase substrate: Lipid II-based molecule possessing a dansyl-C20
polyprenyl moiety. Org. Lett. 2010, 12 (7), 1608-1611. (IF: 5.42) (corresponding author, 4/55 in chemistry, organic)
34. Cheng, T.-J. R.; Wu, Y.-T.; Yang,
S.-T.; Lo, K.-H.; Chen, S.-K.; Chen, Y.-H.; Huang, W.-I.; Yuan, C.-H.; Guo,
C.-W.; Huang, L.-Y.; Chen, K.-T.; Shih, H.-W.; Cheng, Y.-S. E.; Cheng, W.-C.;
Wong, C.-H.*, High-throughput identification of antibacterials against
methicillin-resistant Staphylococcus
aureus (MRSA) and the transglycosylase. Bioorg. Med. Chem. 2010, 18 (24), 8512-8529. (IF:
2.822) (co-author,
12/55 in chemistry, organic)
35. Chan, T.-H.; Chang, Y.-F.; Hsu, J.-J.; Cheng, W.-C.*, Straightforward
synthesis of diverse 1-deoxyazapyranosides via stereocontrolled nucleophilic
additions to six-membered cyclic nitrones. Eur. J. Org. Chem. 2010, 2010
(29), 5555-5559. (IF: 3.206) (corresponding author, 13/56
in chemistry, organic)
36. Tsou, E.-L.; Yeh, Y.-T.; Liang, P.-H.; Cheng, W.-C.*, A convenient
approach toward the synthesis of enantiopure isomers of DMDP and ADMDP. Tetrahedron
2009, 65 (1),
93-100. (IF: 3.219, times cited: 24) (corresponding author, 16/55 in chemistry, organic)
37. Sung, M.-T.; Lai, Y.-T.; Huang, C.-Y.;
Chou, L.-Y.; Shih, H.-W.; Cheng, W.-C.;
Wong, C.-H.*; Ma, C.*, Crystal structure of the membrane-bound bifunctional
transglycosylase PBP1b from Escherichia
coli. Proc. Natl. Acad. Sci. U. S. A. 2009, 106 (22), 8824-8829. (IF: 9.432, times
cited: 20) (co-author,
3/42 in multidisciplinary, science)
38. Shih, H.-W.; Guo, C.-W.; Lo, K.-H.;
Huang, M.-Y.; Cheng, W.-C.*, Solution-phase
parallel synthesis of novel spirooxazolinoisoxazolines. J. Comb. Chem. 2009,
11 (2), 281-287. (IF:
3.45, times cited: 3) (corresponding author, 2/61 in
chemistry, applied)
39. Tsou, E.-L.; Chen, S.-Y.; Yang, M.-H.;
Wang, S.-C.; Cheng, T.-J. R.*; Cheng,
W.-C.*, Synthesis and biological evaluation of a 2-aryl
polyhydroxylated pyrrolidine alkaloid-based library. Bioorg. Med. Chem. 2008,
16 (24), 10198-10204.
40. (IF: 2.822, times cited: 10) (corresponding author, 12/55 in chemistry, organic)
41. Shih, H.-W.; Cheng, W.-C.*, Solution-phase parallel synthesis of highly
diverse spiroisoxazolinohydantoins. Tetrahedron Lett. 2008, 49 (6), 1008-1011. (IF: 2.66, times
cited: 10); (corresponding
author, 21/55 in chemistry, organic)
42. Huang, C.-M.; Liu, R.-S.; Wu, T.-S.; Cheng, W.-C.*, Structural
establishment of polygalatenosides A and B by total synthesis. Tetrahedron
Lett. 2008, 49 (18),
2895-2898. (IF: 2.66, times cited: 3); (corresponding author, 21/55 in chemistry, organic)
43. Cheng, T.-J. R.; Sung, M.-T.; Liao,
H.-Y.; Chang, Y.-F.; Chen, C.-W.; Huang, C.-Y.; Chou, L.-Y.; Wu, Y.-D.; Chen,
Y.-H.; Cheng, Y.-S. E.; Wong, C.-H.*; Ma, C.*; Cheng, W.-C.*, Domain requirement of moenomycin binding to
bifunctional transglycosylases and development of high-throughput discovery of
antibiotics. Proc. Natl. Acad. Sci. U.S.A. 2008, 105 (2), 431-436. (IF: 9.432, time
cited: 15); (corresponding
author, 3/42 in multidisciplinary,
science)
44. Chang, Y.-F.; Liu, C.-Y.; Guo, C.-W.;
Wang, Y.-C.; Fang, J.-M.*; Cheng,
W.-C.*, Solid-phase organic synthesis of polyisoprenoid alcohols with
traceless sulfone linker. J. Org. Chem. 2008, 73 (18), 7197-7203. (IF: 4.219, times
cited: 8); (corresponding
author, 7/55 in chemistry, organic)
45. Chang, Y.-F.; Jiang, Y.-R.; Cheng, W.-C.*, Traceless sulfone
linker cleavage triggered by ozonolysis: solid-phase synthesis of diverse α,
β-unsaturated carbonyl compounds Tetrahedron Lett. 2008, 49 (3), 543-547. (IF: 2.66, times cited:
6); (corresponding
author, 21/55 in chemistry, organic)
46. Liang, P.-H.; Cheng, W.-C.; Lee, Y.-L.; Yu, H.-P.; Wu, Y.-T.; Lin, Y.-L.; Wong,
C.-H., Novel five-membered iminocyclitol derivatives as selective and potent
glycosidase inhibitors: New structures for antivirals and osteoarthritis. ChemBioChem
2006, 7, 165-173. (co-author,
7/41 in chemistry, medicinal)
47. Sanna, M. G.; Wang, S.-K.;
Gonzalez-Cabrera, P. J.; Don, A.; Marsolais, D.; Matheu, M. P.; Wei, S. H.;
Parker, I.; Jo, E.; Cheng, W.-C.;
Cahalan, M. D.; Wong, C.-H.; Rosen, H., Enhancement of capillary leakage and
restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat.
Chem. Biol. 2006, 2, 434-441. (co-author)
48. Sawkar, A. R.; Adamski-Werner, S. L.; Cheng,
W.-C.; Wong, C.-H.; Beutler, E.; Zimmer, K.-P.; Kelly, J. W., Gaucher
Disease-Associated Glucocerebrosidases Show Mutation-Dependent Chemical
Chaperoning Profiles. Chem. Biol. 2005, 12, 1235-1244. (co-author)
49. Best, M. D.; Brik, A.; Chapman, E.;
Lee, L. V.; Cheng, W.-C.; Wong, C.-H., Rapid discovery of potent
sulfotransferase inhibitors by diversity-oriented reaction in microplates
followed by in situ screening. ChemBioChem 2004, 5,
811-819. (co-author)
50. Sawkar, A. R.; Cheng, W.-C.;
Beutler, E.; Wong, C.-H.; Balch, W. E.; Kelly, J. W., Chemical chaperones
increase the cellular activity of N370S beta -glucosidase: a therapeutic
strategy for Gaucher disease. Proc. Natl. Acad. Sci. U. S. A. 2002,
99, 15428-15433. (co-author)
51. Cheng, W.-C.; Wong, M.; Olmstead, M. M.; Kurth, M.
J., Solid-Phase Synthesis of Novel Isoxazolocyclobutanones and
Isoxazolinocyclobutenones. Org. Lett. 2002, 4, 741-744. (First author)
52. Cheng, W.-C.; Liu, Y.; Wong, M.; Olmstead, M. M.;
Lam, K. S.; Kurth, M. J., Stereoselective Synthesis of Unnatural
Spiroisoxazolinoproline-Based Amino Acids and Derivatives. J. Org. Chem. 2002,
67, 5673-5677. (First author)
53. Cheng, W.-C.; Lin, C.-C.; Kurth, M. J., Dimsyl
anion in the monoalkylation of solid-phase alkyl sulfones. Tetrahedron Lett.
2002, 43, 2967-2970. (First
author)
54. Cheng, W.-C.; Kurth, M. J., The Sulfone Linker in
Solid-Phase Synthesis: Preparation of 3,5-Disubstituted Cyclopent-2-enones. J.
Org. Chem. 2002, 67, 4387-4391. (First author)
55. Cheng, W.-C.; Kurth, M. J., The Zincke reaction. A
review. Org. Prep. Proced. Int. 2002, 34, 585,587-608. (First author)
56. Cheng, W.-C.; Olmstead, M. M.; Kurth, M. J., Vinyl
sulfones in solid-phase synthesis: preparation of 4,5,6,7-tetrahydroisoindole
derivatives. J. Org. Chem. 2001, 66, 5528-5533. (First author)
57. Cheng, W.-C.; Halm, C.; Evarts, J. B.; Olmstead, M.
M.; Kurth, M. J., Allylic Sulfones in Solid-Phase Synthesis: Preparation of
Cyclobutylidenes. J. Org. Chem. 1999, 64, 8557-8562. (First author)
Invited talks and oral presentation
1.
Department of Chemical
Engineering, National Cheng Kung University, Taiwan, 2004,
2.
Department of Chemistry,
National Cheng Kung University, Taiwan, 2005
3.
Department of Chemistry,
National Tsing Hua University, Taiwan, 2006
4.
Department of Applied
Chemistry, National Defense University, Taiwan, 2006
5.
The CSJ (Chemical society of Japan) Asian International Symposium, Japan,
2007.
6.
Department of Chemistry, Tamkang University, Taiwan, 2007.
7.
Department of Chemistry, National
Chiayi University, Taiwan 2008
8.
Pre-symposium of the 9th
International Symposium on Organic Reactions-Workshop on Frontier Organic
Synthesis and Glycoscience, National Tsing Hua
University, Taiwan, 2008
9.
Department of Chemistry,
National Chung Hsing University, Taiwan, 2009
10.
Department of Applied
Chemistry, National Chiao Tung University, Taiwan,
2009.
11.
Department of Chemistry, Chung
Shan Medical University, Taiwan, 2009
12.
The
7th International Symposium for Chinese Medicinal Chemists (ISCMC2010), Taiwan,
2010.
13.
The 25th international
symposium of glycosciences, Taiwan, 2010
14.
The 2010 Mini-symposium on
chemical biology, Taiwan, 2010
15.
BIT's 1st Annual World Congress of Microbes-2011, Beijing, China
16.
2013- RIKEN-Academia Sinica
Joint Conference, Taipei, Taiwan
17.
The Joint Symposium of UC Davis and Academia Sinica
Taiwan, USA, 2013
18.
5th
AGCC, Khon Kaen, Thailand,
2013.
19.
Canada-Asia glycoscience
Symposium, Vancouver, Canada, 2014.
20.
Glycobiology and Glycochemistry, New Taipei City, Taiwan, 2015
21.
2015 PST
Medicinal Chemistry Symposium, Nantou, Taiwan, 2015.
22.
RIKEN-Academia
Sinica Joint Conference on Chemical Biology, Oct, 2015
23.
Glycoscience Symposium, Academia Sinica, Taipei,
Taiwan, Nov, 2015
24.
The 10th International
Conference on Cutting-Edge Organic Chemistry in Asia(ICCEOCA-10)& The
1st Advanced Research Network on Cutting-Edge Organic Chemistry in Asia(ARNCEOCA-1, Kaohsiung, Taiwan, Nov 2015
25.
The
international Chemical Congress of Pacific Basin Societies 2015, Hawaii, USA,
Dec, 2015
26.
Tenth
International Symposium for Chinese Medicinal Chemistry, 10th ISCMC, Miaoli ,
Taiwan, 2016.
27.
Bilateral
symposium of GRC-Osaka Univ, Japan, 2016
28.
The Joint Symposium of Peking Univ and Academia
Sinica Taiwan, Taipei, 2016.
29.
The 11th International Conference on Cutting-Edge Organic Chemistry in
Asia / The 2nd Advanced Research Network on Cutting-Edge Organic Chemistry in
Asia, Korea, 2016.
30.
8th AGCC Annual Conference (Asian Community of
Glycoscience and Glycotechnology), Wuxi, China, 2016
31.
Department of Medicinal and
Applied Chemistry, Kaohsiung Medical Univ, Taiwan, 2017
32.
Department of Chemistry,
National Central University, Taiwan, 2017
33.
Department of Entomology, National
Taiwan University, Taiwan, 2017
34.
254th ACS National Meeting &
Exposition,
Washington, DC, US, 2017
35.
Bilateral
symposium of GRC-Osaka Univ, Taiwan, 2017
36.
Department of Chemistry, Tamkang
University, New Taipei City, Taiwan, 2017
37.
24th IUBMB
CONGRESS & 15th FAOBMB CONGRESS, Seoul, 2018
38.
The 10th Asian Community of Glycoscience and Glycotechnology, Tainan, Taiwan ,
2018
39.
Bilateral
symposium of GRC-Osaka Univ, Japan, 2018
40.
Bilateral
symposium of GRC- University of the Philippines
Manila’s , Philippine, 2018