邱秀貞 副教授
一、學歷 2003/2 Ph.D. 美國德拉威大學化學 化學暨生物化學系 (Advisor: Prof.Charlie
G. Riordan)
1996/6 B.S. 彰化師範大學 化學系 二、經歷 2022/2-
嘉義大學
環安中心主任 2018/2-2022/1 嘉義大學 環安中心 環保組 2010/8- 嘉義大學 副教授 2005/8-2010/7 嘉義大學 助理教授 2004/8-2005/7 清華大學化學系 博士後研究
1996/8-1998/7 彰化師範大學 研究助理
三、專業領域 Bioinorganic/organicmetallic
Chemistry (生物無機/有機金屬化學 ) Metal biomedical
materials (金屬生物醫學材料) NO
Release Agent for Repellent / Attraction of Mosquito (一氧化氮蚊蟲忌避/誘引材料之開發) Development
of cosmetic materials (妝品材料之開發) 四、連絡方式 Location:
應化一館 A17-303 Tel:
05-271-7951 Email: genechiou@mail.ncyu.edu.tw 五、研究方向 1. 本實驗室之研究精神啟發於自然,研究基礎則為鐵基一氧化氮釋放分子(Iron-based nitric oxide release molecule, Fe-NORM 例如Roussin’s Red Esters, RREs)之合成,從小分子Fe-NORM至聚合奈米微胞,其性質、結構、一氧化氮釋放之條件、量之調整,乃至於Fe-NORM中引入各式螢光基團追蹤藥物進入生物體之路徑與反應機制,均是實驗室之研究重點,最後更可回饋自然,用其研究埃及斑蚊之生長抑制,亦可作為使腫瘤周邊血管正常化之潛力抗癌偕同藥物,芘基系列分子(Pyrene-Fe-NORM)已確認可運用於發光材料與能源產清之催化劑。 2.
具體產業應用:
埃及斑蚊防治、醫藥-抗癌偕同藥物、發光材料 六、期刊論文: 校務系統研究成果 1.
Chieh-Wei Chung, Bo-Wen Liao, Shu-Wei Huang, Show-JenChiou,
Cheng HanChang, Sheng-JuLin, Bo-Hao Chen, Wei-Ling Liu, Shang-Hsiu Hu, Yu-Chun
Chuang, Chia-Her Lin, I-Jui Hsu, Chao-Min Cheng, Chieh-Cheng Huang, and Tsai-Te
Lu* Magnetic Responsive Release of Nitric Oxide from an MOF-Derived Fe3O4 @PLGA
Microsphere for the Treatment of Bacteria-Infected Cutaneous Wound ACS Applied Materials and Interfaces 2022, 14(5), 6343-6357. 2.
Yun-Chieh Sung1,2, Pei-Ru
Jin1, Li-An Chu3, Fu-Fei Hsu4, Mei-Ren Wang5,
Chih-Chun Chang1, Show-Jen Chiou6, Jiantai
Timothy Qiu7,8,9, Dong-Yu Gao1, Chu-Chi Lin9,
Yu-Sing Chen9, Yi-Chiung Hsu10, Jane Wang2,
Fu-Nien Wang11, Pei-Lun Yu11, Ann-Shyn Chiang 3,12,13,14,
Anthony Yan-Tang Wu15,16,17, John Jun-Sheng Ko1,15,
Charles Pin-Kuang Lai 15,16,18, Tsai-Te Lu 1,5*
Yunching Chen 1*, Delivery of nitric oxide with a
nanocarrierpromotes tumour vessel normalization and potentiates anti-cancer
therapies. Nature Nanotechnology, 2019, 12,
1160-1169. 3.
Tsai-Te Lu*,†, Yun-Ming
Wang*,‡, Chen-Hsiung Hung*,§, Show-Jen Chiou*,
Wen-Feng Liaw*, Bioinorganic Chemistry of the Natural Fe(NO)2 Motif:
Evolution of a Functional Model for NO-Related Biomedical Application and
Revolutionary Development of a Translational Model. Inorg Chem, 2018, 57, 12425-12443. 4.
Tsai-Te Lu, Hsiao-Wen Huang, Chia-Her
Lin, Yu-Ting Tseng, Wen-Feng Liaw, Hsi-Ya Huang, Show-Jen Chiou “DINITROSYL
IRON COMPLEX, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, COMPOSITE MATERIAL
COMPRISING THE SAME, AND USES THEREOF” U.S. Patent Application No. 15/413,428,
January 24, 2017. 5.
Show-Jen Chiou; Yu-Der Wen, "
Effects of curcumin on nitrosyl-iron complex-mediated DNA cleavage and
cytotoxicity. Rong-Jen Shiau, Jheng-Yu Wu,," Planta Med,
2012, 78, 1342-1350. 6.
Show-Jen Chiou 1,
Arnold L. Rheingold 2, Glenn P.A. Yap, Charles G. Riordan,
Coordination chemistry of pyrazolylbis((alkylthio)methyl)borates: Hybrid
nitrogen and sulfur donor ligands, Inorganica Chimica Acta., 2010, 364,
81-88. 7.
Chien-Hong Chen*, Show-Jen Chiou,*,and
Hsuan-Yin Chen, Dinuclear [{Fe(NO)2}10-{Fe(NO)2}10] Dinitrosyl Iron Complex
with Thiolate-CO-Bridged Ligands, Inorg. Chem., 2010, 49,
2023-2025. 8.
Yu-Der Wen, Yun-Lung Ho, Rong-Jen
Shiau, Jung-Kai Yeh, Jheng-Yu Wu, Wei-Lung Wang, Show-Jen Chiou*, Synergistic
antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma
cells, J. Organomet Chem., 2010, 695, 352. 9.
H.-H. Chang; H.-J. Huang; Y.-L. Ho; Y.-D. Wen;
W.-N. Huang; S.-J. Chiou*.The water-soluble Roussin’s red ester acting as a
potential photochemical NO-delivery agent: Photolysis reactions, DNA cleavage
and anticancer activity. Dalton Trans, 2009, 6396.
10. S.-J Chiou*;
C.-C. Wang, C.-M. Chang, Synthesis of dinitrosyl iron complexes (DNICs) with
intramolecular hydrogen bonding. JOMC, 2008, 693,
3582. 七、研討會論文 1. Development of a novel plant extract for mosquito repellent and
attractant. ICOM (19), 2018/11/24-2018/11/26, Taichung Taiwan. 2. Dinitrosyl Iron Complexes
with Bischromophoric Pyrene for Water Splitting, CSLT, 2017/12/01-2017/12/02,
Chiayi Tauwan. 3. 新穎斑蚊忌避與誘引劑複合植物萃液液之開發, CSLT,
2017/12/01-2017/12/02, Chiayi Taiwan. 4. Roussin’s Red Esters as Luminescent Sensors and Carriers of
Nitric Oxide, TBIC, 2016/11/15, Kaohsiung Taiwan. 5. Synthesis of Photochemical NO–Release Molecules (NO-RMs) with
Biomolecular Vectors and their Anticancer Activity. ICBIC(16)
2013/7/22-2013/7/26 Grenbole France 6. Synthesis of Potential Photochemical NO–Release Molecules
(NO-RM), DNICs & RREs with Specific Biomolecular Vectors. ASBIC(6)
2012/11/5-2012/11/8 Hongkong China 八、研究/委辦計畫 1. 2021/01/01-2021/01/15咖啡葉萃取液面膜研發委辦計畫(農委會) 2. 2020/01/01-2020/12/31咖啡葉萃取液保養品研發計畫(農委會) 3. 2017/06/01-2018/10/31產學合作計畫-新穎蚊子忌避與誘引劑材料之開發、測試與應用。(科技部) 4. 2015/09/01-2016/05/31創新環保綠色商機:複合型天然美白化妝品開發整合服務計畫。(SBIR) 5. 2014/08/01-2015/07/31水相光敏含螢光基團具一氧化氮釋放能力之金屬錯合物:合成,特質, DNA斷切及抗癌能力之探討。(科技部) 6. 2014/06/20-2014/10/20化妝保養品中天然抗UV原料的創新與開發。(經濟部) 7. 2011/08/01-2014/07/31 水溶性、光敏含鐵一氧化氮化合物之設計合成、性質、 DNA切割及抗癌活性之探討。(國科會) 8. 2010/08/1-2011/7/31 由結合氨基酸及胜 之水溶性 2-雙羥甲基磷 -1-硫醇乙烷所修飾之亞硝化鐵錯合物 :合成、特性、 DNA斷切及抗腫瘤效應之探討。( 國科會) 9. 2009/08/01-2010/07/31 潛力之光化學一氧化氮藥物前驅物之合成、光反應、DNA切割及蛋白質活化。( 國科會) 10. 2008/08/01-2009/07/31生化擬態之DNIC及RRE性質探討:結構及一氧化氮釋放對DNA切割及蛋白質。( 國科會) 10. 2007/08/01-2008/07/31生化擬態之DNIC及RRE性質探討:結構及一氧化氮釋放對DNA切割及蛋白質活化的影響。( 國科會) 十、教授課目 無機化學、觸媒化學、高等無機化學、有機金屬化學、生物無機化學、環境化學特論、通識-科學與生活、通識-化學與生活 實驗室成員:
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