李瑜章 教授                       

一、學歷：

1995 美國羅徹斯特化學博士 U. of Rochester
(Advisor: Prof. Richard H. Schlessinger)

1987 清華大學化學研究所
  
1985 清華大學化學系

1996/8-2003/7 朝陽科技大學應用化學系副教授

2003/8-2011/7 嘉義大學應用化學系暨研究所副教授

2011/8- 嘉義大學應用化學系暨研究所教授

2013/2-2018/1 嘉義大學國際事務長

2019/8-2022/7 嘉義大學應用化學系系主任

　　E-mail:yjli@mail.ncyu.edu.tw

五、研究方向/ Research Interests：不對稱反應實驗室介紹

　My research interest has been focused on the studies of ;

1.chiral [2,3]-Wittig rearrangement of g -allyloxy substituted vinylogous urethane enolates

2. [3,3]-Claisen rearrangement of g-allyloxy substituted vinylogous urethanes.

3. Total synthesis of Dendrobatidae Alkaloids (Indolizidine 167B, 209B,209D, 209I, 195G, 223A, 3-epi-223AB, 223AB & 205B)

4. Synthesis of highly-substituted oxetanes

5. [1,2]-Wittig rearrangement of gama-benzyloxy vinylogous urethanes and their synthetic applications.

2014/09/162015/07/21

2015/12/222016/02/262019/05/15

六、期刊著作/ Publications (2015-)：校務系統研究成果 

1. Total synthesis of Indolizidine Alkaloids (-)-167B, (-)-209I, and (-)-223A by Using a Common Tricyclic Lactone. Yu-Jang Li,* Chung-Chien Hou, and Kuei-Chen Chang. Eur. J. Org. Chem. 2015, 1659-1663. Supported by MOST-103-2113-M-415-009-. IF = 3.065. (19/59, Chemistry, Organic)

   

    

2. Stereoselective Synthesis of 2,3,4-highly Substituted Oxetanes by Intramolecular C-C Bond Forming Michael Addition, Guo-Ming Ho and Yu-Jang Li*. Chem. Commun, 2016, 52, 12108-12111. DOI: 10.1039/C6CC06857J. Supported by NSC 101-2113-M-415-002, MY2. IF =6.319. (14/157, Chemistry, Multidisciplinary). Reviewed by V. Snieckus, B. P. Schuff on SYNFACTS, 2016, 12, 1242. " Stereoselective Preparation of Substituted Oxetanes"

   

3. Discovery of New Stilbene Antioxidants of the Bio-Elicited Peanut Sprout Powder (BPSP) and Longevity Extension of Mice Fed with BPSP-Supplemented Diets. Robin Y.-Y. Chiou*, Po-Chang Chiu, Ju-Chun Chang, Yu-Jang Li, Chia-Wen Hsieh, Jin-Yi Wu, Shu-Mei Lin, Yun-Lian Lin, Brian B. C. Weng. Food and Nutrition Science, 2017, 8, 141-162.                                                                                                    

   

4. anti-Selective aldol reactions of chiral alcohol-substituted gama-benzyloxyl vinylogous urethanes and the synthesis of 3-benzyloxyl-4-hydroxylalkane-2-ones. Yu-Jang Li*, Chuan-Chung Chung, Pin-Zu Chen. Tetrahedron: Asymmetry 2017, 28, 1573-1581. https://doi.org/10.1016/j.tetasy.2017.10.003.  Supported by MOST-89-2113-M-324-003, MOST-105-2113-M-415-005. IF=2.379. (22/59, Chemistry, Organic)

    

5. Tandem [1,2]-Wittig Rearrangement/Lactonization of gama-benzyloxy vinylogous urethanes: Application to the Synthetic studies of Maculalactone A, Planchol C and gama-Lycorane. Guo-Ming Ho, Yu-Jang Li*. Asian J. Org. Chem. 2018,  7, 145-149. http://dx.doi.org.10.1002/ajoc.201700589. Supported by NSC-100-2119-M-415-001. IF=2.788. (20/59, Chemistry, Organic)

   

6. Peroxidase characterization isolated from germinated peanut embryos (GPE) and application of the freezed-dried GPE powder as emzyme source for biomimetic production of delta-viniferin. Po-Chang Chiu, Yu-Jang Li, Robin Y.-Y. Chiou*. J. Procbio. 2018, 66, 97-105. DOI: 10.1016/j.procbio.2017.11.019.  

7. C-H Functionalization of Amino Alcohols by Osmium Tetroxide/NMO oor TPAP/NMO: Protection Group-Free Synthesis of Indolizidines (-)-223AB and 3-epi-(-)-223AB. Wei-Lun Chen, Lee-Ya Wang, Yu-Jang Li*. Eur. J. Org. Chem. 2020, 103-107. http://dx.doi.org/10.1002/ejoc.201901494 .

8.  Inhibition of testosterone-mediated benign prostatic enlargement of orchiectomized Sprague-Dawley rats by diets supplemented with bio-elicited peanut sprout powder (BPSP) and three new BPSP-extracted natural compounds identified.  Cheng, P.-H., P.-C. Chiu, J.-C. Chang, S.-M. Lin, Y.-J. Li, D.-Y. Lo, L.-R. Lai, S.-C. Wu and R. Y.-Y. Chiou*. J. Functional Foods, 2021.79 (2021) 104383.

Undergraduate research students were indicated in blue color.  

七、 研討會論文 / Conferences (2015-)

1. 25th Congress of International Society of Heterocyclic Chemistry, ISHC. Short talk 0090, page 75, " Asymmetric Synthesis of Poison Dart Frog Indolizidine Alkaloids".  Yu-Jang Li, Aug 23-28, 2015, UC Santa barbara, USA.
2. The 10th International Conference on Cutting Edge Organic Chemistry in Asia, ICCEOCA-10. PO-C2, page 89. " Tatal Synthesis of Poison Frog Alkaloids". Yu-Jang Li, Chung-Chien Hou, Kuei-Chen Chang and Rou-Jie Huang. Nov. 2-5, 2015. Kaohsiung, Taiwan.
3. 2015 展望 秋季演講系列, 台灣無比精彩(二)-傑出科技成就大觀, "我會忘了我自己嗎? -由熱帶雨林箭毒蛙到阿茲海默藥物開發", 李瑜章. 2015, 11月27日. 台灣大學物理系暨天文物理研究所/國立自然科學博物館. 知識大講堂
4. 化學會 104年會研討會論文摘要 OR-099, " Total Synthesis of Dart Frog Indolizidine 167B, 209I and 223A" , Yu-Jang Li, Chung-Chien Hou, Kuei-Chen Chang, 2015年12月5~6日. National Dong Hua University, Hua-Liang.
5. 化學會 104年會研討會論文摘要 OR-098, " Total Synthesis of Dart Frog Indolizidine 209B and 209D" , Yu-Jang Li, Lee-Ya Wang, Kui-Chen Chang and Rou-Jie Huang,  2015年12月5~6日. National Dong Hua University, Hua-Liang.
6. 化學會 104年會研討會論文摘要 OR-0104, " Total Synthesis of Dart Frog Indolizidine 195G" , Yu-Jang Li, Rou-Jie Huang, 2015年12月5~6日. National Dong Hua University, Hua-Liang.
7. 中國化學會 104年會研討會論文摘要 OR-097, " Total Synthesis of Dart Frog Indolizidine 223V" , Yu-Jang Li, Cheng-Chiao Li, 2015年12月5~6日. National Dong Hua University, Hua-Liang.
8. The 12th International Symposium on Organic Reactions (ISOR-2016), SIL-16B, " Total Synthesis Poison Frog Indolizidine Alkaloids." , Yu-Jang LI, Chung-Chien Hou, Kuei-Chen Chang, Rou-Jie Huang, Lee-Ya Wang, Cheng-Chiao Li, April 22-24, 2016, Kyoto. Japan.
9. ACP-2016-Korea, The 11th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-11). PO-D-13," Applications of Rearrangements of gamma-Allyloxy and gamma-Benzyloxy Vinylogous Urethanes Toward Natural Product Synthesis", Yu-Jang LI, Chung-Chien Hou, Kuei-Chen Chang, Rou-Jie Huang, Lee-Ya Wang, Cheng-Chiao Li, Guo-Ming Ho, Oct 27-30, 2016, KAIST (Daejeon), Korea.
10. International Symposium on Catalysis and Fine Chemicals 2016, C & FC 2016, IL-32. "reactions and Applications Toward Natural Product Synthesis of gamma-Allyloxy and gamma-Benzyloxy Vinylogous Urethanes " Nov 10-14, 2016,  Taipei.
11. 化學會 105年會研討會論文摘要 O-075, " Studies on the Synthesis of Penibruguieramine A" , Yu-Jang Li,Wei-Lun Chen, 2016年12月3~4日. National Chung Hsing University, Taichung.
12. 26th Congress of International Society of Heterocyclic Chemistry, ISHC, poster II-13, " Synthetic Application of g-Benzyloxyl Vinylogous Urethanes".  Yu-Jang Li, Sep 3-8, 2017, University of Regensburg, Germany.
13. The 12th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-12), poster B4, " Applications of g-Benzyloxy Vinylogous Urethanes Toward Natural Products and Oxetane Derivative Synthesis". Guo-Ming Ho, Chung-Chien Hou, Cheng-Chiao Li, Yu-Jang Li. Nov. 2-5, 2017. Xi'an China.
14. 化學會106年會研討會論文摘要OR-033, "1,3-Oxazolidine and 1,3-oxazines synthesis from oxidative coupling of pyrrolidine with hydroxyl-tethered."Yu-Jang Li, Lee-Ya Wang, Wei-Lun Chen Yen-Shen Liu. 2017年12月1-2日. National Chiayi University, Chiayi.
15. The 13th International Symposium on Organic Reactions (ISOR-13), SIL-6A, "Oxidative Cyclization of Cyclic Tertiary Amines with Tethered Hydroxy Group Mediated by Osmium Tetroxide." Lee-Ya Wang, Wei-Lun Chen, Yu-Jang Li, Nov. 21-24, 2018. Hsinchu, NCTU.
16. 化學會107年會研討會論文摘要OR-0132, " Protection Free Synthesis of Indolizidine 223AB Analog.", Wei-Lun Chen, Lee-Ya Wang, Yu-Jang Li. 2018年12月8-9日, NSYSU, Kaohsiung.
17. The 20th Tetrahedron Symposium, P1-87, "Oxidative cyclization of cyclic tertiary amines with tethered hydroxy group mediated by osmium tetroxide and the protection free synthesis of indolizidine 223AB." June 18-21, 2019. Bangkok, Thailand.
18. 化學會107年會研討會論文摘要 OR-072. "Catalytic Oxidative Cyclization of Cyclic Aminoalcohols by Osmium tetroxide/NMO or TPAP/NMO and the Protecting Group-Free Synthesis of Indolizidine 223AB and 3-epi-223 AB". Wei-Lun Chen, Lee-Ya Wang, Yu-Jang Li, 2019, Dec 8-12, Taipei, NTU.
19. 化學會2021年會研討會論文摘要 P1-OR-104. "Synthetic Studies Toward BCD Rings of Serratine-Type Alkaloids". Hsiang-Yu Chuang, Yu-Jang Li, 2021, Mar 12-14, Chung-Li, NCU.
20. 化學會2021年會研討會論文摘要 P1-OR-129. "固態聚合物吸附四氧化鋨與四氧化釕催化還氮醇之氧化環化研究". 許晏菱, 陳泓叡 ,李瑜章, 2021, Mar 12-14, Chung-Li, NCU.
21. 化學會2022年會研討會 (IL-Org 1) "Total Synthesis of indolizidine type natural products" Wei-Lun Chen, Chung-Chien Hou, Kui-Chen Chang, Hsiang-Yu Chung, Yu-Jang Li*, 2022, Mar 11-13, Taipei, NTNU.
22. The 15th International Symposium on Organic Reactions (ISOR-15), " Syntthesis and Reactions of a-Aminal-b-Hydroxycycloamines", Hong-Rui Chen, Guan-Yu Lu, Bing-Yi Cai and Yu-Jang Li, 2022, Nov. 3-5, Taichung. 中興大學.
23. 化學會2023年會研討會 (Sun-4-017), " Synthesis and 1,2-rearrangement of a-aminal-b-hydroxycycloamines", Guan-Yu Lu, Bing-Yi Cai and Yu-Jang Li*, 2023, Mar 10-12, Kaohsiung. 高雄大學.

八、研究計畫/ Research Grants：

九、教授課目：

有機化學、有機反應、有機光譜、藥物化學、觸媒化學

十、實驗室照片(Lab Photos)

 2015                       167B, 209I, 223A合成慶祝         

十一、其他：

TVBS世界翻轉中- 新藥研發訪問影片