1.
Chi
MC, Lo HF, Lin MG, Chen YY, Wang TF*, Lin LL*(2019) Mutational analysis
of a highly conserved PLSSMXP sequence in the small subunit of Bacillus
licheniformis γ-glutamyltranspeptidase. Biomolecules, 9:508
2.
Wang
TF, Lo HF*, Chi MC, Lai KL, Lin MG, Lin LL*(2019) Affinity
immobilization of a bacterial prolidase onto metal-ion-chelated magnetic
nanoparticles for the hydrolysis of organophosphorus compounds. International
Journal of Molecular Sciences, 20:3625
3.
Chi
MC, Lin MG, Huang YF, Chen YY, Wang TF*, Lin LL*(2019) Enzymatic
synthesis of L-theanine from L-glutamine and ethylamine by Bacillus
licheniformis γ-glutamyltranspeptidase and its mutants specialized in
transpeptidase activity. Biocatalysis and Agricultural Biotechnology,
22:101393
4.
Lo
HF, Chi MC, Lin MG, Lan YG, Wang TF*, Lin LL*(2018) Protective effect of
biological osmolytes against heat- and chaotropic agent-induced denaturation of
Bacillus licheniformis γ-glutamyltranspeptidase. Journal of Microbiology
and Biotechnology, 28: 1457-1466
5.
Lee
YC, Chi MC, Lin MG, Chen YY, Lin LL*, Wang TF*(2018) Biocatalytic
synthesis of γ-glutamyl-L-leucine, a kokumi-imparting dipeptide, by Bacillus
licheniformis γ-glutamyltranspeptidase. Food Biotechnology,
32:130-147
6.
Wang
TF, Chi MC, Lai GL, Lin MG, Chen YY, Lo HF*, Lin LL*(2018) High-level
expression and molecular characterization of a recombinant prolidase from
Escherichia coli NovaBlue. PeerJ, 6: e5863
7.
Chi
MC, Lo HF, Lin MG, Chen YY, Lin LL*, Wang TF*(2017) Application of
Bacillus licheniformis γ-glutamyltranspeptidase to the biocatalytic synthesis
of γ-glutamyl-phenylalanine. Biocatalysis and Agricultural Biotechnology,
10: 278-284
8.
Lin
LL, Chi MC, Lan EG, Lin MG, Juang TY*, Wang TF*(2017) Facile
immobilization of Bacillus licheniformis γ-glutamyltranspeptidase onto graphene
oxide nanosheets and its application to the biocatalytic synthesis of
γ-L-glutamyl peptides. International Journal of Biological Macromolecules,
117: 1326-1333
9.
Chi
MC, Lin MG, Chen YY, Lin LL*, Wang TF*(2017) Functional role of the
conserved glycine residues, Gly481 and Gly482, of the γ-glutamyltranspeptidase
from Bacillus licheniformis. International Journal of Biological
Macromolecules, 109: 1182-1188
10. Lin LL, Chi MC, Lan EG, Lin MG, Juang TY*, Wang TF*(2017) Facile
immobilization of Bacillus licheniformis γ-glutamyltranspeptidase onto graphene
oxide nanosheets and its application to the biocatalytic synthesis of
γ-L-glutamyl peptides. International Journal of Biological Macromolecules,
17: S0141-8130
11. Chi MC, Lin MG, Chen YY, Lin LL*, Wang TF*(2017) Functional
role of the conserved glycine residues, Gly481 and Gly482, of the
γ-glutamyltranspeptidase from Bacillus licheniformis. International
Journal of Biological Macromolecules, 109:1182-1188
12.
Lin MG, Chi MC, Chen YY, Wang TF, Lo
HF*, Lin LL* (2016) Site-directed mutagenesis of a conserved
Asn450 residue of Bacillus licheniformis γ-glutamyltranspeptidase. International Journal
of Biological Macromolecules 91:416-425.
13.
Wang CH, Huang
CC, Lin LL, Chen W* (2016) The effect of disulfide bonds on
protein folding, unfolding, and misfolding
investigated by FT–Raman spectroscopy. Journal of Raman SpectroscopyDOI:
10.1002/jrs.4935.
14.
Lo HF, Chen
BE, Lin MG, Chi MC, Wang TF*, Lin LL* (2016) Gene expression
and molecular characterization of a chaperone protein HtpG from Bacillus
licheniformis. International Journal of Biological Macromolecules 85:179-191.
15.
Lin MG, Wang TF, Chen YY,
Chi MC*, Lin LL* (2016) Effects of organic co-solvents on
catalytic activity and structural stability of three different Bacillus enzymes. Journal
of the Taiwan Institute of Chemical Engineers 59:126-131.
16.
Lin MG, Chi MC, Naveen V, Li YC, Lin
LL*, Hsiao CD* (2016) Bacillus licheniformis trehalose-6-phosphate
hydrolase structures suggest keys to substrate specificity. Acta Crystallographica D72:59-70.
17.
Pica A, Chi MC, D’Ischia M, Chen
YY, Lin LL, Merlino A* (2016) The maturation mechanism of
γ-glutamyltranspeptidases: insights from the crystal structure of a precursor
mimic of the enzyme fromBacillus licheniformis. Biochimica et
Biophysica Acta – Proteins and Proteomics 1864:195-203.
18.
Chen YY, Lo HF, Wang TF, Lin MG, Lin
LL*, Chi MC* (2015) Enzymatic synthesis of γ-L-glutamyl-S-allyl-L-cysteine,
a naturally occurring organosulfur compound from garlic, by Bacillus
licheniformis γ-glutamyltranspeptidase. Enzyme and Microbial
Technology 75-76:18-24.
19.
Liao HF*, Wu DR, Dai JL, Chi MC, Lin
LL* (2015) Immunomodulatory activity of the polysaccharide-rich extract
from edible cyanobacterium Nostoc commune. Medical Science 3(4):112-123.
20.
Chen JH, Chi MC, Lin MG, Lin
LL*, Wang TF (2015) Beneficial effect of sugar osmolytes on the
refolding of guanidine hydrochloride-denatured trehalose-6-phosphate hydrolase
from Bacillus licheniformis.BioMed Research International Article
ID 806847.
21.
Lin MG, Chen BE, Chi MC, Wang TF, Lo HF, Lin
LL* (2015) Tryptophan substitution at three specific phenylalanine
locations of Bacillus licheniformis nucleotide exchange factor
GrpE: structural and functional effects. International Journal of
Biological Macromolecules 72:724-731.
22.
Chi MC, Lo YH, Chen YY, Lin LL*, Merlino
A* (2014) γ-Glutamyl transpeptidase architecture: effect of extra
sequence deletion on autoprocessing, structure and stability of the
protein from Bacillus licheniformis. Biochimica et
Biophysica Acta – Proteins and Proteomics 1844:2290-2297.
23.
Lin LL, Chen YY, Chi
MC, Merlino A* (2014) Low resolution X-ray structure of
γ-glutamyltranspeptidase from Bacillus licheniformis: opened active
site cleft and a cluster of acid residues potentially involved in the
recognition of a metal ion. Biochimica et Biophysica Acta - Proteins
and Proteomics 1844:1523-1529.
24.
Juang TY*, Kan SJ,
Chen YY, Tsai YL, Lin MG, Lin LL* (2014) Preparation of
surface-functionized hyperbranched poly(amido acids) magnetic nanocarriers for
the covalent immobilization of a bacterialγ-glutamyltranspeptidase. Molecules 19:4997-5012.
25.
Ong PL, Chuang TT, Wang TF, Lin
LL* (2014) Identification of critical amino acid residues for
chloride binding of Bacillus licheniformis trehalose-6-phosphate
hydrolase. Biologia 69(1):1-9.
26.
Wang TF, Lin MG, Lo HF, Chi MC, Lin
LL* (2014) Biophysical characterization of a recombinant
aminopeptidase II from the thermophilic bacterium Bacillus
stearothermophilus. Journal of Biological Physics 40:25-40.
27.
Chi MC, Lin MG, Wang TF, Lo HF, Lin
LL* (2013) Influence of asparagine mutations on enzymatic activity and
thermostability of a recombinant α-amylase from alkaliphilic Bacillus sp.
strain TS-23.Journal of Enzyme Research 4:46-49.
28.
Chen YY, Tsai MG, Chi MC, Wang
TF*, Lin LL* (2013) Covalent immobilization of Bacillus
licheniformis γ-glutamyltranspeptidase on aldehyde-functionalized
magnetic nanoparticles. International Journal of Molecular
Sciences 14:4613-4628.
29.
Lin LL, Merlino A*
(2013) Heterogeneous nucleation helps the search for initial crystallization
conditions of γ-glutamyl transpeptidase from Bacillus
licheniformis. Acta Crystallographica F69:669-672.
30.
Ong PL, Chuang TT, Wang TF, Lin
LL*. 2013. Implications of amino acid residues Arg201 and Asn327 on
chloride binding of trehalose-6-phosphate hydrolase, TreA, from Bacillus
licheniformis. Biologia(Under review)
31.
Lo HF*, Chen YZ, Lin LL*. 2013.
Simultaneous purification and immobilization of histidine-taggedBacillus
licheniformis aldehyde dehydrogenase. Journal of Pure and
Applied Microbiology (accepted for publication)
32.
Chen BE, Lin MG, Lo HF, Wang TF, Chi
MC*, Lin LL*. 2013. Introduction of a unique tryptophan
residue into various positions of Bacillus licheniformis DnaK. International
Journal of Biological Macromolecules 52:231-243.
33.
Chi MC, Chen YY, Lo HF, Lin LL*. 2012.
Experimental evidence for the involvement of amino acid residue Glu398 in the
autocatalytic processing of Bacillus licheniformis γ-glutamyltranspeptidase. FEBS
Open Bio 2:298-304.
34.
Hu HY, Yang JC,
Chen JH, Chi MC*, Lin LL*. 2012. Enzymatic
characterization of Bacillus licheniformis γ-glutamyltranspeptidase
fused to N-terminally truncated forms of Bacillus sp.
TS-23 α-amylase. Enzyme and Microbial Technology 50:86-94.
35.
Lee YC*, Lin DT, Chen HL, Lo HF, Hu HY,
NW Hsiao, Lin LL*. 2012. Characterization of glycine
substitution mutations within the NAD+-binding site of Bacillus
licheniformis aldehyde dehydrogenase.Protein & Peptide
Letters 19: 1183-1193.
36.
Chen YH, Chi MC, Wang TF, Chen JC, Lin
LL*. 2012. Preparation of magnetic nanoparticles and their use for
immobilization of C-terminally lysine-tagged Bacillus sp.
TS-23 α-amylase. Applied Biochemistry and Biotechnology 166:1711-1722.
37.
Chuang TT, Ong PL, Wang TF, Huang HB,
Chi MC, Lin LL*. 2012. Molecular characterization of a novel
trehalose-6-phosphate hydrolase, TreA, from Bacillus licheniformis. International
Journal of Biological Macromolecules 50:459-470.
38.
Chi MC, Wu TJ, Chen HL, Lo HF*, Lin
LL*. 2012. Counteraction of temperature- and chemical-induced
denaturation of a recombinant Bacillus sp. TS-23 α-amylase
by sorbitol. Journal of Industrial Microbiology and Biotechnology 39:
1779-1788.
39.
Lee YC, Lin DT, Ong PL, Chen HL, Lo
HF*, Lin LL*. 2011. Contribution of conserved Glu255 and
Cys289 residues to catalytic activity of a recombinant aldehyde dehydrogenase
from Bacillus licheniformis. Biochemistry-Moscow 76:1233-1241.
40.
Lo HF, Su JY, Chen HL, Chen JC, Lin
LL*. 2011. Biophysical studies of a NAD(P)+-dependent aldehyde
dehydrogenase from Bacillus licheniformis. European
Biophysics Journal 40:1131-1142.
41.
Hung CP, Yang JC, Chen JH, Chi MC, Lin
LL*. 2011. Unfolding analysis of the mature and unprocessed forms
of Bacillus licheniformis γ-glutamyltranspeptidase. Journal
of Biological Physics 37:463-475.
42.
Chen HL, Lo HF*, Chang CT, Lin
LL*. 2011. Substrate specificity and kinetic characterization of a
recombinant dipeptidyl carboxypeptidase from Escherichia coli novablue. Research
Journal of Microbiology 6(4):410-417
43.
Yang JC, Liang WC, Chen YY, Chi MC, Lo
HF, Chen HL, Lin LL*. 2011. Biophysical characterization
of Bacillus licheniformis and Escherichia coli γ-glutamyltranspeptidases:
a comparative analysis.International Journal of Biological
Macromolecules 48:414-422.
44.
Lin MG, Liang WC, Chen BE, Chou
WM, Lin LL*. 2011. Involvement of residues Asp8, Asn13,
Glu145, Asp168, and Thr173 in the chaperone activity of a recombinant DnaK
from Bacillus licheniformis. Journal of Molecular
Microbiology and Biotechnology 20:29-42.
45.
Chi MC, Wu DR, Chuang TT, Chen HL, Lo
HF, Lin LL*. 2010. Biophysical characterization of a
recombinant α-amylase from thermophilic Bacillus sp..
TS-23. The Protein Journal 29:572-582. (SCI)
46.
Tsai MY, Chang WH, Liang JY, Lin
LL, Chang GC, Chang HP*. 2010. Essential covalent linkage
between the chymotrypsin-like domain and the extra domain of the SARS-CoV main
protease. Journal of Biochemistry (Tokyo) 149(3):349-358.
47.
Chen YH, Chuang LY, Lo HF, Lin
LL*, Chi MC*. 2010. Mutational analysis of the proposed calcium-binding
aspartates of a truncated α-amylase fromBacillus sp.
strain TS-23. Annals of Microbiology 60(2):307-315.
48.
Lin MG, Chen BE, Liang WC, Chou WM, Kuo
LY, Lin LL*. 2010. Site-saturation mutagenesis of leucine 134
of Bacillus licheniformis nucleotide exchange factor GrpE
reveals the importance of this residue to the co-chaperone activity. The
Protein Journal 29:365-372.
49.
Huang CL, Cheng WC, Yang JC, Chi MC,
Chen JH, Lin HP, Lin LL*. 2010. Preparation of carboxylated
magnetic particles for the efficient immobilization of C-terminally
lysine-tagged Bacillus stearothermophilus aminopeptidase
II. Journal of Industrial Microbiology and Biotechnology 37:717-725.
50.
Chi MC, Chen AH, Wu DR, Lo HF, Lin
LL*. 2010. Engineering of a truncated α-amylase of Bacillus sp.
strain TS-23 for the simultaneous improvement of thermal and oxidative
stabilities. Journal of Bioscience and Bioengineering 109:531-538.
51.
Chang HP, Liang WC, Lyu RC, Chi MC, Wang
ZF, Su KL, Hung HC, Lin LL*. 2010. Effects of C-terminal
truncation on the autocatalytic processing of a
recombinant γ-glutamyltranspeptidase from Bacillus
licheniformis. Biochemistry-Moscow 75(7):919-929.
52.
Chi MC, Chang HP, Chang GG, Wang TF,
Huang HB, Lin LL*. 2010. Biophysical properties of a
recombinant leucyl aminopeptidase from Bacillus kaustophilus. Biochemistry-Moscow 75(5):642-647.